This monograph details humanin, a 24-amino acid peptide derived from mitochondria, outlining its discovery, structure, and significant pharmacological properties. It discusses humanin's protective role in cardiovascular and renal health, its mechanisms of action through various signaling pathways, and its potential as a biomarker for diseases such as acute kidney injury and breast cancer. Additionally, ongoing clinical trials investigating its utility in fertility and chronic kidney disease suggest promising implications for personalized medicine.
Intravenous, Subcutaneous, Research applications
1-100 μM in vitro; dose-dependent studies in clinical trials
Short-lived in circulation
and potency compared to native humanin, making it a preferred candidate for therapeutic development . Cryo-EM structures of humanin complexed with FPR2 provide detailed insights into receptor binding mechanisms .
FPR2 (FPRL2), BAX, BID, IGFBP-3
Humanin is a 24-amino acid mitochondrial-derived peptide (MDP) encoded by the MT-RNR2 gene located within the mitochondrial 16S ribosomal RNA sequence . This unique peptide represents a paradigm shift in understanding mitochondrial function, demonstrating that mitochondria can produce bioactive peptides with systemic effects beyond their traditional role in energy metabolism .
FPR2 (FPRL2)
BAX
BID
Research Use Only (RUO) - Humanin Peptide Research Monograph: Mechanisms & Applications is currently available for research purposes only and is not approved by regulatory agencies for human therapeutic use.
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